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Jan 2024 [New Member]  


Zhao (Carol) Zhang joined the lab as a postdoc scholar. Welcome!

Zhao received her PhD at Clemson Univeristy, focusing on microscopy and bioimaging.

Zhao Zhang_edited_edited_edited.jpg

Dec 2022 [1st PhD]  


Sohyeon Park successfully defended her PhD thesis and became the first graduate from our lab. With our tie-cutting tradition, we hope that her career will soar high!


Aug 2023 [Paper]  


Yinyin published her first review paper in Current Opinion in Structural Biology. Check out:

Y. Zhuang, X. Shi, Expansion microscopy: A chemical approach for super-resolution microscopy,  Current Opinion in Structural Biology 81, 102614 (2023)


July 2023 [Student Award]  


Justin Vien graduated with Excellence in Research honor in Spring 2023! Congratulations on the great achievement in his undergrad research in our lab!! 

Jie Chen Xiaoyu Shi Lab.jpeg
Yuanyuan Wang Xiaoyu Shi Lab.jpeg

May Jun 2023 [New Members]  


CJ (Jie Chen) as assistant project scientist and Yuanyunan Wang as postdoc researcher joined our team. Welcome!! CJ worked on quantum dots and electron microscopy, while Yuanyuan worked on single-cell analysis before joining the lab.

Jan 2023  [Award]


Xiaoyu, Leonel Malacrida (Pasteur Institute of Montevideo), Tatsuo Fukagawa (Osaka University), and Elizabeth Head (UCI) won the Advancing Imaging Through Collaborative Projects grant sponsored by Chan Zuckerberg Initiative for their project "Disseminating Chemical-based Super-resolution Microscopy". They are 1 of the 14 winning teams across the world. [CZI press][Twitter][UCI News]

Oct 2022 [Award]  


Xiaoyu received NIH Director's New Innovator Award for the conceptually novel method GO3D spatial single-cell multiomics.

[NIH press release] [UCI news] [news]

Jul 2022 [Paper]  


Sohyeon experienced Hollywood-style publication, our first joVE video paper on the LR-ExM protocol

Jul 2022 [Award]  


Xiaoyu was awarded a 2022-2023 Hellman Fellowship Award. The grant will empower a new direction in Shi lab that is  “Uncover Cellular Mechanisms of Aging Using Super-Resolution Microscopy.”  [news]

Jun 2022 [Student Award]  


Justin Vien was selected as a SURP Fellow for Summer 2022 by the Undergraduate Research Opportunities Program (UROP) Faculty Advisory Board.


May 2022 [Student Award]  


Congrats to Yinyin for receiving the NSF-Simons fellowship and becoming a 2022-2023 CMCF graduate fellow, for her ground-breaking work on nuclear lamina!  [news]

May 2022 [New Member]  


Sihe Tan joined as a graduate student researcher. Welcome!

Sihe received his BS at UCSB before joining the lab.


May 2022 [New professor]  

[Qualified PhD Candidate]  

[Official lab manager]  


Congratulations to our postdoc Nan for accepting an assistant professor position, to Sohyeon for passing the qualifying exam, to Adrian for officially becoming our lab manager, and to for Sihe for starting his rotation in our lab!

Feb 2022 [Award]  


Shi Lab and Olga Razorenova Lab received an interdisciplinary pilot grant sponsored by UCI Center for Cancer Systems Biology for their collaborative project "inter-organelle crosstalk in the cancer cell nucleus".

Feb 2022 [Celebrate]  

We celebrated Feb 11 International Day of Women and Girls in Science together with Journal of Cell Biology on twitter. Happy research, ladies! Thank you for your contribution to science and human beings! 

Oct 2021 [Stuent Award]  

Sohyeon presented her work on Alzheimer's disease at the 4th Annual Symposium on Multiscale Cell Fate. This project was awarded the Interdisciplinary Opportunity Award

Sep 2021 [Paper]  

Our LR-ExM image of nuclear lamina was featured on the table of contents page of JCB of the September issue.

Aug 2021 [High school]  

This summer, Xiaoyu, Steven, and Shehreen teamed up with three MathExp LR high school students, Tom, Tiana, and Alessandro. They programed a "robotic biologist" who can automatically take images and segment organelles.  So fun!


Jun 2021 [New Member]  

Yinyin Zhuang joined as a graduate student researcher. Welcome on board!

Yinyin got her MS degree at Nanyang Technological University, Singapore.

Jun 2021 [Award]  

Jennifer Prescher and Xiaoyu Shi won the Visual Proteomics Imaging grant sponsored by Chan Zuckerberg Initiative for their project "Chemically Triggered Probes for High-Resolution, Multiplexed Imaging". They are 1 of the 14 winning teams across the world.

[News] [Project]

Jun 2021 [Contest]  

Our lab won the 3rd place of the UCI Art in Science Graphics Contest.

Jun 2021 [New Member]  

Nan Shi joined as the postdoc. Welcome on board! Nan received his PhD degree from Auburn University.


May 2021 [New Scope]  

Our home-built STORM microscope Laguna welcomed her first user Sohyeon.

  • Mar 2021    We welcome our new class of BME undergraduate researchers Steven, Shehreen, Dillon,                                    Sedrick, and Kyubeom!! See you in the lab when you are back to campus.

  • Feb 2021    Our epifluorescence microscope Newport is built on top of a microscope (one of the first                                      confocal in the world) donated by Dr. Francis Szoka. (Thank you, Frank! Your microscope is up                             running again in a new home.)

  • Jan 2021    Our STORM microscope Laguna is built.

  • Oct 2020    Jack Corrette started his rotation in our lab. Welcome!

  • Sep 2020   Katie Fong joined as honored bio199 undergraduate research assistant.

  • Aug 2020   Sohyeon Park, Andrew McColloch, and Khoi Nguyen joined as graduate student researcher, postdoc fellow, and undergraduate research assistant. Welcome, new members! We will make up the welcome lunch at the University Club after the pandemic.​

  • Jan 2020   Jiaxi Zhang joined as the lab manager and junior specialist. Welcome on board!

  • Oct 2018   J. Phy. Chem. A. Cover image.


  • July 2018   Xiaoyu presented Label-Retention Expansion STORM (LR-ExSTORM) at Gordon Research                                  Conference (GRC)  - Single Molecule Approaches to Biology

  • July 14-15  Xiaoyu chaired Gordon Research Seminar  (GRS) Single Molecule Approaches to Biology

  • May 2018   Xiaoyu received K99/R00 NIH Pathway to Independence Award                                 

  • Fed 2018    Xiaoyu chaired Platform: Optical Microscopy and Superresolution Imaging: Applications, at the

                         Biophysical Society 62nd Annual Meeting

  • Fed 2018    Xiaoyu received Mary Anne Koda-Kimble Seed Award

  • Oct 2017    Nat. Cell Biol. Cover image.

  • Aug 2017    Xiaoyu won the Young Artist Award at 25th United States International Music Competition


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